A cryptic subgroup of Anopheles gambiae is highly susceptible to human malaria parasites. Science 2011 Feb 04;331(6017):596-8
Date
02/05/2011Pubmed ID
21292978Pubmed Central ID
PMC3065189DOI
10.1126/science.1196759Scopus ID
2-s2.0-79551636620 (requires institutional sign-in at Scopus site) 108 CitationsAbstract
Population subgroups of the African malaria vector Anopheles gambiae have not been comprehensively characterized owing to the lack of unbiased sampling methods. In the arid savanna zone of West Africa, where potential oviposition sites are scarce, widespread collection from larval pools in the peridomestic human habitat yielded a comprehensive genetic survey of local A. gambiae population subgroups, independent of adult resting behavior and ecological preference. A previously unknown subgroup of exophilic A. gambiae is sympatric with the known endophilic A. gambiae in this region. The exophilic subgroup is abundant, lacks differentiation into M and S molecular forms, and is highly susceptible to infection with wild Plasmodium falciparum. These findings might have implications for the epidemiology of malaria transmission and control.
Author List
Riehle MM, Guelbeogo WM, Gneme A, Eiglmeier K, Holm I, Bischoff E, Garnier T, Snyder GM, Li X, Markianos K, Sagnon N, Vernick KDAuthor
Michelle M. Riehle PhD Assistant Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnopheles
Bayes Theorem
Burkina Faso
Genotype
Host-Parasite Interactions
Housing
Humans
Hybridization, Genetic
Insect Vectors
Larva
Malaria, Falciparum
Microsatellite Repeats
Mosquito Control
Plasmodium falciparum
Polymorphism, Single Nucleotide
Population Dynamics
