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The Rat Genome Database 2009: variation, ontologies and pathways. Nucleic Acids Res 2009 Jan;37(Database issue):D744-9 PMID: 18996890 PMCID: PMC2686558

Pubmed ID

18996890

DOI

10.1093/nar/gkn842

Abstract

The Rat Genome Database (RGD, http://rgd.mcw.edu) was developed to provide a core resource for rat researchers combining genetic, genomic, pathway, phenotype and strain information with a focus on disease. RGD users are provided with access to structured and curated data from the molecular level through to the level of the whole organism, including the variations associated with disease phenotypes. To fully support use of the rat as a translational model for biological systems and human disease, RGD continues to curate these datasets while enhancing and developing tools to allow efficient and effective access to the data in a variety of formats including linear genome viewers, pathway diagrams and biological ontologies. To support pathophysiological analysis of data, RGD Disease Portals provide an entryway to integrated gene, QTL and strain data specific to a particular disease. In addition to tool and content development and maintenance, RGD promotes rat research and provides user education by creating and disseminating tutorials on the curated datasets, submission processes, and tools available at RGD. By curating, storing, integrating, visualizing and promoting rat data, RGD ensures that the investment made into rat genomics and genetics can be leveraged by all interested investigators.

Author List

Dwinell MR, Worthey EA, Shimoyama M, Bakir-Gungor B, DePons J, Laulederkind S, Lowry T, Nigram R, Petri V, Smith J, Stoddard A, Twigger SN, Jacob HJ, RGD Team

Authors

Melinda R. Dwinell PhD Center Associate Director, Associate Professor in the Physiology department at Medical College of Wisconsin
Mary E. Shimoyama PhD Associate Professor in the Biomedical Engineering department at Medical College of Wisconsin




Scopus

2-s2.0-58149194606   54 Citations

MESH terms used to index this publication - Major topics in bold

Animals
Databases, Genetic
Disease
Disease Models, Animal
Genetic Variation
Genome
Genomics
Phenotype
Rats
Signal Transduction
Software
Terminology as Topic
jenkins-FCD Prod-332 f92a19b0ec5e8e1eff783fac390ec127e367c2b5