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Mechanisms and consequences of chromosomal translocation. Cancer Epidemiol Biomarkers Prev 2008 Aug;17(8):1849-51

Date

08/19/2008

Pubmed ID

18708370

Pubmed Central ID

PMC2562255

DOI

10.1158/1055-9965.EPI-07-2902

Abstract

A 2006 National Cancer Institute workshop on chromosomal translocations brought together laboratory, clinical, and population scientists to cross-fertilize and catalyze research on this important disease process. The deliberations revealed significant contrasts between two types of translocations that result in either deregulated expression of oncogenes or formation of novel fusion genes. The classic oncogene-activating translocation, MYC-IGH, has been elucidated in terms of molecular structure and functional consequences yet has little epidemiologic characterization. In comparison, the archetypal fusion-gene translocation, BCR-ABL, has well-described clinical manifestations but is less defined with regard to mechanism of generation. Interdisciplinary collaboration on chromosomal translocations should yield additional insights regarding their biological significance and potential as targets for intervention.

Author List

Rabkin CS, Janz S

Author

Siegfried Janz MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Humans
National Cancer Institute (U.S.)
Oncogenes
Translocation, Genetic
United States
jenkins-FCD Prod-403 0f9a74600e4e79798f8fa6f545ea115f3dd948b2