Contractile and relaxant responses of diabetic dog femoral arteries. Acta Physiol Hung 1988;71(2):213-7
Date
01/01/1988Pubmed ID
3389165Scopus ID
2-s2.0-0023896063 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Strips of femoral arteries of normal and alloxan-treated dogs were set up for isometric recording. The contractile response to phenylephrine and the relaxant response to acetylcholine were determined. Neither alloxan treatment nor mechanical removal of endothelium altered the EC50 value for phenylephrine. The slope of phenylephrine dose-response curves of diabetic and healthy vessels with intact endothelium was similar, whereas the slope of phenylephrine dose-response curves of endothelium-denuded diabetic arteries was significantly greater than that of the denuded healthy arteries. Removal of the endothelium completely abolished the relaxant effect of acetylcholine. The relaxant potency (IC50) of acetylcholine was not affected by alloxan treatment. The results suggest that in canine femoral arteries the relaxant activity of acetylcholine is unaffected in experimental diabetes and the damage of the arterial endothelium may play a role in the increased responsiveness of diabetic vessels to adrenergic agonists.
Author List
Gebremedhin D, Hadházy P, Koltai MZ, Pogátsa GMESH terms used to index this publication - Major topics in bold
AcetylcholineAnimals
Diabetes Mellitus, Experimental
Dogs
Endothelium, Vascular
Female
Femoral Artery
In Vitro Techniques
Male
Muscle Contraction
Muscle Relaxation
Muscle, Smooth, Vascular
Phenylephrine