Mitochondrial regulation of diabetic vascular disease: an emerging opportunity. Transl Res 2018 Dec;202:83-98
Date
08/26/2018Pubmed ID
30144425Pubmed Central ID
PMC6218302DOI
10.1016/j.trsl.2018.07.015Scopus ID
2-s2.0-85052836555 (requires institutional sign-in at Scopus site) 37 CitationsAbstract
Diabetes-related vascular complication rates remain unacceptably high despite guideline-based medical therapies that are significantly more effective in individuals without diabetes. This critical gap represents an opportunity for researchers and clinicians to collaborate on targeting mechanisms and pathways that specifically contribute to vascular pathology in patients with diabetes mellitus. Dysfunctional mitochondria producing excessive mitochondrial reactive oxygen species (mtROS) play a proximal cell-signaling role in the development of vascular endothelial dysfunction in the setting of diabetes. Targeting the mechanisms of production of mtROS or mtROS themselves represents an attractive method to reduce the prevalence and severity of diabetic vascular disease. This review focuses on the role of mitochondria in the development of diabetic vascular disease and current developments in methods to improve mitochondrial health to improve vascular outcomes in patients with DM.
Author List
Widlansky ME, Hill RBAuthor
Michael E. Widlansky MD Associate Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDiabetic Angiopathies
Endothelium, Vascular
Humans
Mitochondria
Mitochondrial Proteins
Reactive Oxygen Species
