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Angioinvasive Fungal Infections Impacting the Skin: Diagnosis, Management, and Complications (Part 2). J Am Acad Dermatol 2018 Aug 10 PMID: 30102950

Pubmed ID

30102950

DOI

10.1016/j.jaad.2018.04.058

Abstract

As discussed in Part I, angioinvasive fungal infections pose a significant risk to immunocompromised and immunocompetent patients alike, with potential for severe morbidity and high mortality. Part I of this CME focused on the epidemiology and clinical presentation of these infections; Part II will discuss diagnosis, management, and potential complications of these infections. The mainstay diagnostic tests (positive tissue culture with histologic confirmation) are often supplemented with serum biomarker assays and molecular testing (e.g., quantitative PCR analysis and MALDI-TOF mass spectrometry) to ensure proper speciation. When an angioinvasive fungal infection is suspected or diagnosed, further work-up for visceral involvement also is essential and may partially depend on the organism. Different fungal organisms demonstrate varied susceptibilities to antifungal agents, and knowledge on optimal treatment regimens is important to avoid potential complications associated with undertreated or untreated fungal infections.

Author List

Berger AP, Ford BA, Brown-Joel Z, Shields BE, Rosenbach M, Wanat KA

Author

Karolyn A. Wanat MD Associate Professor in the Dermatology department at Medical College of Wisconsin




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