Medical College of Wisconsin
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Disseminated CD8-positive, CD30-positive cutaneous lymphoproliferative eruption with overlapping features of mycosis fungoides and primary cutaneous anaplastic large cell lymphoma following remote solitary lesional presentation. J Cutan Pathol 2017 Aug;44(8):703-712 PMID: 28497585

Pubmed ID

28497585

DOI

10.1111/cup.12961

Abstract

CD8-positive, CD30-positive cutaneous lymphoproliferative disorders constitute a rare subset of T-cell lymphoproliferative conditions, including variants of primary cutaneous anaplastic large cell lymphoma (ALCL), mycosis fungoides, lymphomatoid papulosis type D, cutaneous gamma-delta T-cell lymphoma and cutaneous peripheral T-cell lymphoma. These entities share overlapping clinical, histopathologic and immunophenotypic features, presenting both a clinical and pathological diagnostic challenge. Presented here is a 73-year-old man with a disseminated, indolent CD30+, CD8+ cutaneous lymphoproliferative disorder with overlapping clinical and histopathological features of both mycosis fungoides and primary cutaneous ALCL, as well as features of lymphomatoid papulosis. To our knowledge, this is the first case of a generalized CD8+, CD30+ eruption with features of both mycosis fungoides and primary cutaneous ALCL arising following an episode of solitary primary cutaneous CD8-positive ALCL.

Author List

Davick JJ, Mutgi KAJ, Wanat KA, Link BK, Liu V

Author

Karolyn A. Wanat MD Associate Professor in the Dermatology department at Medical College of Wisconsin




Scopus

2-s2.0-85020482135

MESH terms used to index this publication - Major topics in bold

Aged
CD8-Positive T-Lymphocytes
Humans
Ki-1 Antigen
Lymphoma, Large-Cell, Anaplastic
Male
Mycosis Fungoides
Neoplasm Proteins
Skin Neoplasms
jenkins-FCD Prod-310 bff9d975ec7f2d302586822146c2801dd4449aad