Faculty Collaboration Database

Relationship of Aortic Wall Distensibility to Mitral and Aortic Valve Calcification: The Multi-Ethnic Study of Atherosclerosis. Angiology 2018 May;69(5):443-448

Date

10/14/2017

Pubmed ID

29025284

DOI

10.1177/0003319717730636

Scopus ID

2-s2.0-85043351623 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

Data are limited on whether valvular calcification is associated with aortic wall stiffness. We tested whether aortic valve calcification (AVC) and/or mitral valve calcification (MVC) is inversely associated with aortic distensibility (AD). Cross-sectional study conducted in a subset of the Multi-Ethnic Study of Atherosclerosis (MESA) included 3676 MESA participants aged 44 to 84 years with AD measured with magnetic resonance imaging and with AVC and MVC measured with noncontrast cardiac computed tomography scans. Both AVC and MVC were divided into 3 categories: zero, < median values (low), and ≥ median values (high) for patients with nonzero values. Overall, 88% (n = 3256) and 92% (n = 3365) of participants had zero AVC and MVC, while 6% (n = 211) and 4% (n = 156) had low, and 6% (n = 209) and 4% (n = 155) had high values of AVC and MVC, respectively. The AVC was independently associated with AD after adjusting for age, gender, and ethnicity ( P = .035). No association was noted between AVC groups and AD after adjustment for all covariates or MVC groups and AD in any model.

Author List

Cohoon KP, Criqui MH, Budoff MJ, Lima JA, Blaha MJ, Decker PA, Durazo R, Liu K, Kramer H

Author

Kevin Cohoon DO Assistant Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Aortic Valve
Aortic Valve Stenosis
Atherosclerosis
Calcinosis
Cross-Sectional Studies
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Mitral Valve Stenosis
Tomography, X-Ray Computed
Vascular Capacitance