Two-year-old female with EBV-positive diffuse large B-cell lymphoma and subsequent CNS involvement with neurolymphomatosis. Pediatr Blood Cancer 2018 Dec;65(12):e27415
Date
08/29/2018Pubmed ID
30151967Pubmed Central ID
PMC8244825DOI
10.1002/pbc.27415Scopus ID
2-s2.0-85052806933 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
We describe a case of Epstein-Barr virus (EBV) positive, diffuse large B-cell lymphoma in a 2-year-old female who went on to develop relapsed/refractory central nervous system (CNS) disease, manifesting as cranial nerve neurolymphomatosis. Although her atypical presentation was thought to be associated with an immune deficiency, extensive work-up was negative. Despite subsequent treatment with third-party EBV-specific cytotoxic T-lymphocytes, she died of progressive disease. This case report raises questions as to whether tailored treatment approaches should be considered for atypical presentations of pediatric lymphoma (e.g., CNS and virus-associated).
Author List
Bjornard KL, Leventaki V, Nichols KE, Sandlund JT, Prockop S, Ehrhardt MJMESH terms used to index this publication - Major topics in bold
Child, PreschoolEpstein-Barr Virus Infections
Female
Humans
Lymphoma, Large B-Cell, Diffuse