Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

"Toxoplasma Encephalitis following Tandem Autologous Hematopoietic Stem Cell Transplantation: A Case Report and Review of the Literature, Case Reports in Infectious Diseases Vidya Kollu, "Toxoplasma Encephalitis following Tandem Autologous Hematopoietic Stem Cell Transplantation: A Case Report and Review of the Literature," Case Reports in Infectious Diseases, vol. 2018, Article ID 9409121, 3 pages, 2018

Abstract

Infection with Toxoplasma gondii is a rare but often fatal complication in hematopoietic stem cell transplantation (HSCT) recipients. Most cases have been reported in allogeneic (allo-) HSCT recipients, with only narrative reports following autologous HSCT (ASCT). We report the case of a 58-year-old Caucasian male presenting with toxoplasma encephalitis following tandem ASCT for myeloma and successfully treated with diagnosis by polymerase chain reaction analysis of cerebrospinal fluid. He was treated with sulfadiazine and pyrimethamine (with leucovorin) followed by pyrimethamine and atovaquone as secondary prophylaxis while receiving subsequent therapy for progressive multiple myeloma. Toxoplasmosis is a potential complication in allo-HSCT as well as ASCT recipients and should be considered in any post-HSCT patient with neurological dysfunction. Rapid diagnosis and immediate antimicrobial treatment are essential to avoid morbidity and mortality.

Author List

Vidya Kollu, Guido Tricot, Margarida Silverman, Dilek Ince

Author

Vidya Kollu MD Assistant Professor in the Medicine department at Medical College of Wisconsin


View Online
jenkins-FCD Prod-296 4db9d02597e0a2e889e230f853b641c12f1c3ee3