Genetic determinants of hypertension: an update. Curr Hypertens Rep 2008 Dec;10(6):488-95
Date
10/31/2008Pubmed ID
18959837DOI
10.1007/s11906-008-0091-1Scopus ID
2-s2.0-58949094003 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
Hypertension represents a global public health burden. In addition to the rarer Mendelian forms of hypertension, classic genetic studies have documented a significant heritable component to the most common form, essential hypertension (EH). Extensive efforts are under way to elucidate the genetic basis of this disease. Recently, a new form of Mendelian hypertension has been identified, pharmacogenetic association studies in hypertensive patients have identified novel gene-by-drug interactions, and the first genome-wide association studies of EH have been published. New findings in consomic and congenic rat models also offer new clues to the genetic architecture of this complex phenotype. In this review, the authors summarize and evaluate the most recent findings related to hypertension gene identification.
Author List
Harrison M, Maresso K, Broeckel UAuthor
Ulrich Broeckel MD Chief, Center Associate Director, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCohort Studies
Disease Models, Animal
Female
Gene Expression Regulation
Genetic Linkage
Genetic Predisposition to Disease
Genome
Humans
Hypertension
Male
Phenotype
Rats
Sensitivity and Specificity
