Metabolic rate regulation by the renin-angiotensin system: brain vs. body. Pflugers Arch 2013 Jan;465(1):167-75
Date
04/12/2012Pubmed ID
22491893Pubmed Central ID
PMC3569511DOI
10.1007/s00424-012-1096-9Scopus ID
2-s2.0-84873056337 (requires institutional sign-in at Scopus site) 24 CitationsAbstract
Substantial evidence supports a role for the renin-angiotensin system (RAS) in the regulation of metabolic function, but an apparent paradox exists where genetic or pharmacological inhibition of the RAS occasionally has similar physiological effects as chronic angiotensin infusion. Similarly, while RAS targeting in animal models has robust metabolic consequences, effects in humans are more subtle. Here, we review the data supporting a role for the RAS in metabolic rate regulation and propose a model where the local brain RAS works in opposition to the peripheral RAS, thus helping to explain the paradoxically similar effects of RAS supplementation and inhibition. Selectively modulating the peripheral RAS or brain RAS may thus provide a more effective treatment paradigm for obesity and obesity-related disorders.
Author List
Grobe JL, Rahmouni K, Liu X, Sigmund CDAuthors
Justin L. Grobe PhD Professor in the Physiology department at Medical College of WisconsinCurt Sigmund PhD Chair, Professor in the Physiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsBrain
Energy Metabolism
Homeostasis
Humans
Renin-Angiotensin System