Isotype switch-mediated CH deletions are a recurrent feature of Myc/CH translocations in peritoneal plasmacytomas in mice. Int J Cancer 2002 Oct 10;101(5):423-6
Date
09/07/2002Pubmed ID
12216069DOI
10.1002/ijc.10638Scopus ID
2-s2.0-0037057518 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Oncogene activating chromosomal translocations that interrupt IGH switch (S) regions at 14q32 are thought to be caused by misguided IGH isotype switching in postgerminal center B-cell lymphomas and plasma cell myelomas in humans. Aberrant switching also seems to be involved in altering the fine structure of the translocation in some of these tumors, but the significance of these changes is not known. Here we report on 3 cases of IL-6 transgenic mouse plasmacytomas (PCT) that harbor T(12;15) translocations that had been modified by frustrated switch attempts that result in C(H) deletions. When considered together with 6 similar cases of PCT described previously, our observations suggest that secondary deletions in C(H) are a regular feature in the molecular evolution of T(12;15) translocations and, thereby, in the progression of PCT. We propose that the T(12;15)(+) mouse PCT offers a uniquely valuable model system for elucidating the dual role of abnormal isotype switching in causation and 'remodeling' of chromosomal translocations.
Author List
Kovalchuk AL, Janz SAuthor
Siegfried Janz MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBase Sequence
Chromosome Mapping
Genes, myc
Humans
Immunoglobulin Class Switching
Immunoglobulin Heavy Chains
Immunoglobulin Isotypes
Interleukin-6
Mice
Mice, Inbred BALB C
Mice, Transgenic
Peritoneal Neoplasms
Plasmacytoma
Sequence Deletion
Translocation, Genetic