Migration of cells with immunoglobulin/c-myc recombinations in lymphoid tissues of mice. Blood 1997 Jan 01;89(1):291-6
Date
01/01/1997Pubmed ID
8978304Scopus ID
2-s2.0-0038079015 (requires institutional sign-in at Scopus site) 29 CitationsAbstract
Recombinations between c-myc and immunoglobulin (Ig) sequences that typically occur in pristane-induced mouse plasmacytomas were detected in secondary lymphoid tissues from normal mice, chiefly in the gut-associated lymphoid tissue. Based on the analysis of recombination sequences as clonotypic markers, migration of c-myc recombination-positive cells was observed between Peyer's patches and into the intestine. Treatment of plasmacytoma-susceptible BALB/cAn mice with pristane induced proliferation and migration of these cells into mesenteric lymph node, spleen, and oil granuloma within 7 days. Plasmacytoma-resistant strains of mice (DBA/2N, C3H/HeJ, C57BL/6) differed in that (1) they harbored fewer clones (Ig/c-myc recombinations were detected in 33% of resistant mice versus 91% of BALB/cAn mice after pristane treatment); (2) Ig/c-myc-positive cells were rarely detected in the oil granuloma, and (3) c-myc recombined predominantly with the Ig alpha locus in BALB/cAn mice (72%), but with the Ig mu locus in DBA/2N and in C57BL/6 (67%). The results demonstrate that normal mice generate a large number of lymphocytes with aberrant c-myc in intestinal tissues without developing tumors.
Author List
Müller JR, Jones GM, Janz S, Potter MAuthor
Siegfried Janz MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBase Sequence
Cell Differentiation
Cell Movement
DNA, Neoplasm
Disease Susceptibility
Genes, Immunoglobulin
Genes, myc
Immunity, Innate
Immunoglobulin Heavy Chains
Lymphoid Tissue
Mice
Mice, Inbred Strains
Organ Specificity
Plasmacytoma
Polymerase Chain Reaction
Recombination, Genetic
Terpenes
Time Factors