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Illegitimate recombinations between c-myc and immunoglobulin loci are remodeled by deletions in mouse plasmacytomas but not in Burkitt's lymphomas. Curr Top Microbiol Immunol 1995;194:425-9

Date

01/01/1995

Pubmed ID

7895518

DOI

10.1007/978-3-642-79275-5_49

Abstract

Recombinations between c-myc and immunoglobulin loci are a hallmark of Burkitt's lymphomas and mouse plasmacytomas. Analyzing the fine structure of these illegitimate rearrangements has revealed differences between the recombinations in these two tumors. Recombinations are nearly reciprocal in Burkitt's lymphomas, whereas in most BALB/c plasmacytomas large stretches of c-myc sequences have been deleted. The recombinations detected during preneoplastic development of plasmacytomas, in contrast, have most of the c-myc sequences retained on either one of the translocated chromosomes. We conclude that initial recombination structures are subjected to secondary changes in mouse plasmacytomas. In Burkitt's lymphomas the primary recombination sequence is preserved in tumor cells.

Author List

Müller JR, Janz S, Potter M

Author

Siegfried Janz MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Base Sequence
Burkitt Lymphoma
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 8
Genes, Immunoglobulin
Genes, myc
Granuloma
Humans
Immunoglobulin Heavy Chains
Mice
Mice, Inbred Strains
Molecular Sequence Data
Peritonitis
Plasmacytoma
Polymerase Chain Reaction
Precancerous Conditions
Recombination, Genetic
Sequence Alignment
Sequence Deletion
Terpenes
Translocation, Genetic
jenkins-FCD Prod-400 0f9a74600e4e79798f8fa6f545ea115f3dd948b2