Medical College of Wisconsin
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Induction of plasma cell tumours with 2,6,10,14-tetramethylpentadecane (pristane) and paraffin oil (paraffinum perliquidum) in BALB/c mice simultaneously exposed to sustained antigenic stimulation with bovine serum albumin (BSA). Arch Geschwulstforsch 1987;57(1):25-30

Date

01/01/1987

Pubmed ID

3566462

Abstract

Plasmacytomas were readily induced in BALB/c mice by three bimonthly i.p. injections of 0.5 ml pristane or paraffin oil. Additionally, two groups of mice were simultaneously given a prolonged antigenic stimulation with bovine serum albumin (BSA). The tumour incidence found in mice treated with pristane and BSA (75%) was higher than the plasmacytoma incidence in mice subjected to paraffin oil and BSA inoculations (53.7%, p = 0.05). The sustained antigenic stimulation with BSA had no effect on cumulative plasmacytoma incidence.

Author List

Janz S, PĆ¼schel W, Raabe F, Storch H

Author

Siegfried Janz MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Antigens
Carcinogens
Female
Immunization
Male
Mice
Mice, Inbred BALB C
Mineral Oil
Oils
Paraffin
Plasmacytoma
Serum Albumin, Bovine
Terpenes
Time Factors
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