Faculty Collaboration Database

Magnetic resonance brain tumor imaging in canine glioma. Neurology 1987 Jul;37(7):1235-9

Date

07/01/1987

Pubmed ID

3601090

DOI

10.1212/wnl.37.7.1235

Scopus ID

2-s2.0-0023262488 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

This study investigates a canine model of experimental brain tumor. Particularly addressed was the usefulness of gadolinium contrast-enhanced MRI for differentiating brain tumor tissue from cerebral edema. Cultured canine glioma cells were injected into the left hemispheres of six adult mongrel dogs. All dogs developed brain tumors. Serum samples drawn prior to and serially after tumor inoculation showed development of antibodies reactive to the tumor. All tumors were visualized with MRI. Contrast-enhanced T1-weighted imaging was the most sensitive with gadolinium producing tumor enhancement due to blood-brain barrier breakdown. Gross and microscopic autopsy findings correlated well with MRIs.

Author List

Whelan HT, Clanton JA, Moore PM, Tolner DJ, Kessler RM, Whetsell WO Jr

MESH terms used to index this publication - Major topics in bold

Animals
Antibodies, Neoplasm
Brain Neoplasms
Cell Line
Dogs
Gadolinium
Gadolinium DTPA
Glioma
Magnetic Resonance Spectroscopy
Organometallic Compounds
Pentetic Acid