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Myoelectric and contractile effects of motilin on dog small intestine in vivo. Dig Dis Sci 1986 Oct;31(10):1062-72

Date

10/01/1986

Pubmed ID

3757721

DOI

10.1007/bf01300259

Scopus ID

2-s2.0-0022534853   1 Citation

Abstract

The effects of the close intraarterial administration of motilin on intestinal myoelectric and contractile activities were examined in 37 dogs. After anesthetization or decerebration, a segment of proximal jejunum was instrumented serosally with electrodes and stain gauges. A mesenteric artery supplying a short length of this segment was cannulated for the injection of motilin and other agents. Motilin (0.03-0.3 microgram) caused: a series (1-5 min) of phasic contractions and electrical response activity (ERA) bursts locally; a short (15-60 sec) series of phasic contractions and ERA bursts aborally followed by relaxation; and a series of phasic contractions and ERA bursts whose onset migrated 3.7 +/- 1.0 cm orally. The length of orad response increased to 6.6 +/- 1.9 cm in the decerebrate dogs (P less than 0.01). No other tested agent, including serotonin, bethanechol, morphine, dopamine, substance P, neurotensin, somatostatin, vasoactive intestinal peptide, bombesin, pentagastrin, cholecystokinin octapeptide, prostaglandin F2 alpha or leucine-enkephalin, caused similar responses. All motilin responses were mediated by neural pathways consisting of both nicotinic and muscarinic receptors. The similarity of responses and mechanisms of action of the motilin-activated contractile response with the intrinsic mucosal reflex suggested that motilin may mediate this reflex.

Author List

Lang IM, Sarna SK, Condon RE

Author

Ivan M. Lang DVM, PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Dogs
Female
Gastrointestinal Motility
Jejunum
Male
Motilin
Muscle Contraction
Neural Pathways
Reflex
jenkins-FCD Prod-411 e00897e83867fcfa48419861683711f8d99adb75