Effectiveness of a six-drug regimen (APO) without local irradiation for treatment of mediastinal lymphoblastic lymphoma in children. Cancer 1985 Aug 15;56(4):738-41
Date
08/15/1985Pubmed ID
3839432DOI
10.1002/1097-0142(19850815)56:4<738::aid-cncr2820560406>3.0.co;2-oScopus ID
2-s2.0-0021961222 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
Fourteen children with mediastinal lymphoblastic lymphoma (MLL) were treated with the six-drug APO protocol. This regimen includes aggressive intermittent chemotherapy and prophylactic central nervous system therapy. Mediastinal irradiation was given only for emergency relief of mediastinal compression (two children) or for incomplete resolution of mediastinal widening with chemotherapy (one child). All 14 patients achieved complete remission; only 1 has relapsed. Toxicities were not severe. APO is effective therapy for children with MLL. APO should receive further trials in children and adults with T-cell lymphoblastic lymphomas.
Author List
Camitta BM, Lauer SJ, Casper JT, Kirchner PA, Kun LE, Oechler HW, Adair SEMESH terms used to index this publication - Major topics in bold
AdolescentAntineoplastic Combined Chemotherapy Protocols
Asparaginase
Child
Child, Preschool
Doxorubicin
Female
Humans
Lymphoma, Non-Hodgkin
Male
Mediastinal Neoplasms
Mercaptopurine
Methotrexate
Prednisone
Vincristine
