Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Cholangitis associated with Cryptococcus neoformans. Gastroenterology 1985 Apr;88(4):1055-9 PMID: 3972225

Pubmed ID

3972225

Abstract

A 15-yr-old girl presented with complaints of right upper quadrant pain and jaundice. Elevation of serum alkaline phosphatase, signs of protal hypertension, and computed tomographic scan findings suggested a diagnosis of primary sclerosing cholangitis. However, cultures of the bile and of the common bile duct specimen obtained during a surgical procedure grew Cryptococcus neoformans. Treatment with amphotericin B was begun. An episode of upper gastrointestinal bleeding, however, led to the hepatorenal syndrome, and the patient died before antifungal therapy was completed. At autopsy, active sclerosing cholangitis associated with cryptococci involved the common bile duct. We suggest that opportunistic infection of the biliary tree should be considered in pediatric patients with presumed primary sclerosing cholangitis.

Author List

Bucuvalas JC, Bove KE, Kaufman RA, Gilchrist MJ, Oldham KT, Balistreri WF

Author

Keith T. Oldham MD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Cholangiography
Cholangitis
Cryptococcosis
Female
Humans
Liver
Necrosis
Tomography, X-Ray Computed
jenkins-FCD Prod-321 98992d628744e349846c2f62ac68f241d7e1ea70