Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Long-term treatment of plastic bronchitis with aerosolized tissue plasminogen activator in a Fontan patient. Pediatr Crit Care Med 2005 Jan;6(1):76-8 PMID: 15636664

Pubmed ID

15636664

Abstract

OBJECTIVE: To report the successful treatment of plastic bronchitis with aerosolized tissue plasminogen activator.

DESIGN: Case report.

PATIENTS: A 4-yr-old boy with congenital heart disease, who developed plastic bronchitis 33 months after a Fontan operation

INTERVENTIONS: Long-term treatment with aerosolized tissue plasminogen activator.

MEASUREMENTS AND MAIN RESULTS: We describe the case of a boy who developed recurrent episodes of life-threatening airway obstruction secondary to plastic bronchitis. Following the failure of multiple therapeutic interventions, his condition improved significantly with aerosolized tissue plasminogen activator. Several attempts to wean him off this treatment resulted in clinical deterioration. He has remained on long-term aerosolized tissue plasminogen activator.

CONCLUSION: Treatment of plastic bronchitis with aerosolized tissue plasminogen activator may benefit patients in whom other therapies have failed.

Author List

Wakeham MK, Van Bergen AH, Torero LE, Akhter J

Author

Martin K. Wakeham MD Associate Professor in the Pediatrics department at Medical College of Wisconsin




Scopus

2-s2.0-21744458795   39 Citations

MESH terms used to index this publication - Major topics in bold

Administration, Inhalation
Airway Obstruction
Bronchiolitis Obliterans
Child, Preschool
Fontan Procedure
Heart Defects, Congenital
Humans
Male
Plasminogen Activators
Recurrence
Tissue Plasminogen Activator
Treatment Outcome
jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796