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Mesh term TRPC6 Cation Channel

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Calcium Channels
TRPC Cation Channels

Description

A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.



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jenkins-FCD Prod-310 bff9d975ec7f2d302586822146c2801dd4449aad