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Mesh term Carcinoid Heart Disease

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Heart Diseases
Malignant Carcinoid Syndrome

Description

Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.



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jenkins-FCD Prod-130 96200611f8481f0aa4f84230b11dd74d063847a3