Mesh term Kininogens
Browse to parent terms:Blood Coagulation Factors
Kinins
Protein Precursors
Description
Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.Browse to child terms:
Kininogen, High-Molecular-Weight
Kininogen, Low-Molecular-Weight
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