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Mesh term Nitric Oxide

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Free Radicals
Nitrogen Oxides
Reactive Nitrogen Species

Description

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.



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jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e