Mesh term Tetrahydrofolate Dehydrogenase
Browse to parent terms:Oxidoreductases Acting on CH-NH Group Donors
Description
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.Search for this term in our Faculty Database
View this term at the NCBI website