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Mesh term Dystrophin

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Cytoskeletal Proteins
Membrane Proteins
Muscle Proteins

Description

A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.



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jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e