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Mesh term Mice, Knockout

Browse to parent terms:
Mice, Mutant Strains
Mice, Transgenic

Description

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.


Browse to child terms:
Mice, 129 Strain
Mice, Knockout, ApoE


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jenkins-FCD Prod-410 e9586552fe7f53c71f7923aa6e27aeabbd3c2473