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Mesh term Integrin alphaVbeta3

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Platelet Membrane Glycoproteins
Receptors, Vitronectin

Description

An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).



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jenkins-FCD Prod-310 bff9d975ec7f2d302586822146c2801dd4449aad