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Mesh term Receptors, Tumor Necrosis Factor, Type I

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Receptors, Death Domain
Receptors, Tumor Necrosis Factor

Description

A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.



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jenkins-FCD Prod-332 f92a19b0ec5e8e1eff783fac390ec127e367c2b5