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Mesh term PTEN Phosphohydrolase

Browse to parent terms:
Intracellular Signaling Peptides and Proteins
Phosphoric Monoester Hydrolases
Tumor Suppressor Proteins

Description

A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.



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jenkins-FCD Prod-310 bff9d975ec7f2d302586822146c2801dd4449aad