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Mesh term Transforming Growth Factor beta1

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Transforming Growth Factor beta

Description

A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.



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jenkins-FCD Prod-200 8231f2114cbb5b433e24eeafff71f933aa5694c5