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Mesh term Leukemia, Large Granular Lymphocytic

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Leukemia, T-Cell

Description

A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.



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jenkins-FCD Prod-310 bff9d975ec7f2d302586822146c2801dd4449aad