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Mesh term Agouti Signaling Protein

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Intercellular Signaling Peptides and Proteins

Description

A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.



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jenkins-FCD Prod-310 bff9d975ec7f2d302586822146c2801dd4449aad