CD36: implications in cardiovascular disease. Int J Biochem Cell Biol 2007;39(11):2012-30
Date
05/01/2007Pubmed ID
17466567Pubmed Central ID
PMC2034445DOI
10.1016/j.biocel.2007.03.012Scopus ID
2-s2.0-34548482011 (requires institutional sign-in at Scopus site) 202 CitationsAbstract
CD36 is a broadly expressed membrane glycoprotein that acts as a facilitator of fatty acid uptake, a signaling molecule, and a receptor for a wide range of ligands, including apoptotic cells, modified forms of low density lipoprotein, thrombospondins, fibrillar beta-amyloid, components of Gram positive bacterial walls and malaria infected erythrocytes. CD36 expression on macrophages, dendritic and endothelial cells, and in tissues including muscle, heart, and fat, suggest diverse roles, and indeed, this is truly a multi-functional receptor involved in both homeostatic and pathological conditions. Despite an impressive increase in our knowledge of CD36 functions, in depth understanding of the mechanistic aspects of this protein remains elusive. This review focuses on CD36 in cardiovascular disease-what we know, and what we have yet to learn.
Author List
Febbraio M, Silverstein RLAuthor
Roy L. Silverstein MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCD36 Antigens
Cardiovascular Diseases
Humans
Insulin Resistance
