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Dusp-5 and Snrk-1 coordinately function during vascular development and disease. Blood 2009 Jan 29;113(5):1184-91

Date

10/18/2008

Pubmed ID

18927432

Pubmed Central ID

PMC2635084

DOI

10.1182/blood-2008-06-162180

Scopus ID

2-s2.0-60849096090   46 Citations

Abstract

Mitogen-activated protein kinases play an integral role in several cellular processes. To regulate mitogen-activated protein kinases, cells express members of a counteracting group of proteins called phosphatases. In this study, we have identified a specific role that one member of this family of phosphatases, dual-specific phosphatase-5 (Dusp-5) plays in vascular development in vivo. We have determined that dusp-5 is expressed in angioblasts and in established vasculature and that it counteracts the function of a serine threonine kinase, Snrk-1, which also plays a functional role in angioblast development. Together, Dusp-5 and Snrk-1 control angioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snrk-1. Importantly, mutations in dusp-5 and snrk-1 have been identified in affected tissues of patients with vascular anomalies, implicating the Snrk-1-Dusp-5 signaling pathway in human disease.

Author List

Pramanik K, Chun CZ, Garnaas MK, Samant GV, Li K, Horswill MA, North PE, Ramchandran R

Authors

Paula E. North MD, PhD Professor in the Pathology department at Medical College of Wisconsin
Ramani Ramchandran PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Blood Vessels
Dual-Specificity Phosphatases
Gene Expression Regulation
Hemangioma
Humans
Mesoderm
Mutation
Neoplasm Proteins
Protein-Serine-Threonine Kinases
Signal Transduction
Zebrafish
Zebrafish Proteins
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d