Production of human B and T cell growth factors is enhanced by thymic hormones. Immunopharmacology 1988;16(2):97-105
Date
09/01/1988Pubmed ID
3264553DOI
10.1016/0162-3109(88)90018-5Scopus ID
2-s2.0-0023678973 (requires institutional sign-in at Scopus site) 27 CitationsAbstract
The thymic preparations thymosin fraction 5 (TF5) and synthetic thymosin alpha 1 (T alpha 1) were examined for their ability to enhance growth factor production by human peripheral blood mononuclear cells (PBMC). The results showed that both TF5 and T alpha 1 were capable of enhancing the production of a B cell growth factor (BCGF-12kD) and T cell growth factor (TCGF; IL-2). Enhancement by T alpha 1 could be obtained at 100-200-fold lower concentrations than that seen with TF5. In contrast, no enhancement of growth factor production was obtained with control preparations of non-thymic tissue extracts at any concentrations used. It was observed that stimulation of BCGF-12kD and IL-2 was most significantly obtained when the PBMC were activated with lectin. Furthermore, no direct effect of thymic hormones on test B and T cells was observed. These observations provide the first direct evidence that production of B cell growth factors can be enhanced by thymic hormones. In addition, these studies suggest that thymic hormones may regulate B cell responses by acting on mature activated T lymphocytes.
Author List
Kouttab NM, Goldstein AL, Lu M, Lu L, Campbell B, Maizel ALAuthor
Bruce H. Campbell MD Emeritus Professor in the Otolaryngology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
B-LymphocytesHumans
In Vitro Techniques
Interleukin-2
Interleukin-4
Interleukins
Kinetics
Lymphocyte Activation
T-Lymphocytes
Thymosin
Thymus Hormones
