Genetics of valvular heart disease. Curr Cardiol Rep 2014;16(6):487
Date
04/20/2014Pubmed ID
24743897Pubmed Central ID
PMC4531840DOI
10.1007/s11886-014-0487-2Scopus ID
2-s2.0-84901336620 (requires institutional sign-in at Scopus site) 53 CitationsAbstract
Valvular heart disease is associated with significant morbidity and mortality and often the result of congenital malformations. However, the prevalence is increasing in adults not only because of the growing aging population, but also because of improvements in the medical and surgical care of children with congenital heart valve defects. The success of the Human Genome Project and major advances in genetic technologies, in combination with our increased understanding of heart valve development, has led to the discovery of numerous genetic contributors to heart valve disease. These have been uncovered using a variety of approaches including the examination of familial valve disease and genome-wide association studies to investigate sporadic cases. This review will discuss these findings and their implications in the treatment of valvular heart disease.
Author List
LaHaye S, Lincoln J, Garg VAuthor
Joy Lincoln PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAnticoagulants
Aortic Valve
Child
Ebstein Anomaly
Genome-Wide Association Study
Heart Defects, Congenital
Heart Valve Diseases
Heart-Assist Devices
Humans
Life Expectancy
Mitral Valve Prolapse
Prevalence
Pulmonary Valve Stenosis
