Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development. Dev Biol 2006 Jun 15;294(2):292-302
Date
04/29/2006Pubmed ID
16643886DOI
10.1016/j.ydbio.2006.03.027Scopus ID
2-s2.0-33745102721 (requires institutional sign-in at Scopus site) 167 CitationsAbstract
The mature heart valves are dynamic structures composed of highly organized cell lineages and extracellular matrices. The discrete architecture of connective tissue within valve leaflets and supporting structures allows the valve to withstand life-long functional demands and changes in hemodynamic forces and load. The dysregulation of ECM organization is a common feature of heart valve disease and can often be linked to genetic defects in matrix protein structure or developmental regulation. Recent studies have identified specific regulatory pathways that are active in the developing valve structures and also control cartilage, tendon, and bone development. This review will focus on the regulatory hierarchies that control normal and abnormal heart valve development in parallel with other connective tissue cell types.
Author List
Lincoln J, Lange AW, Yutzey KEAuthor
Joy Lincoln PhD Chief, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AggrecansAnimals
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins
Bone and Bones
Carrier Proteins
Cartilage
Cathepsin K
Cathepsins
Chondroitin Sulfate Proteoglycans
Connective Tissue Diseases
Extracellular Matrix Proteins
Fibroblast Growth Factors
Heart Valves
Hemodynamics
High Mobility Group Proteins
Lectins, C-Type
Membrane Glycoproteins
NFATC Transcription Factors
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
SOX9 Transcription Factor
Tenascin
Tendons
Transcription Factors
Transforming Growth Factor beta
