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Maturation of secretory function in rat pancreas. Pediatr Res 1982 Feb;16(2):123-5

Date

02/01/1982

Pubmed ID

6173837

DOI

10.1203/00006450-198202000-00009

Scopus ID

2-s2.0-0020041764 (requires institutional sign-in at Scopus site)   29 Citations

Abstract

In contrast to morphologic maturity, the newborn rat pancreas is unresponsive to carbachol. At 24 h, carbachol-stimulated secretion of exportable proteins markedly increases. Responsiveness to the calcium ionophore, A23187, is present at term. At age 24 h, pancreas from fasted newborn rats is also unresponsive to carbachol. When cholecystokinin octapeptide or hydrocortisone was administered to fasted newborn rats secretory function developed normally. Thus, responsiveness of newborn rat pancreas to secretagogues matures rapidly and can be induced by hormones.

Author List

Werlin SL, Stefaniak J

Author

Steven L. Werlin MD Emeritus Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Amylases
Animals
Animals, Newborn
Calcimycin
Carbachol
Cholecystokinin
Chymotrypsinogen
Fetus
Hydrocortisone
Pancreas
Pancreatic Juice
Peptide Fragments
Rats
Rats, Inbred Strains
Sincalide