Faculty Collaboration Database

Predicting outcomes of neonates born to GBS-positive women who received inadequate intrapartum antimicrobial prophylaxis. Turk J Pediatr 2014;56(3):238-42

Date

10/25/2014

Pubmed ID

25341594

Scopus ID

2-s2.0-85006294879 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

We determined the predicting factors of early-onset group B streptococcal (EOGBS) infection in neonates who were born to GBS carrier mothers with inadequate intrapartum antibiotic prophylaxis (IAP). Medical records of all neonates born from January 1, 2008 to April 1, 2010 were reviewed. Inadequate IAP was defined as delivery less than 4 hours (h) after the first administration of antimicrobial. Of 1910 neonates, 273 were born from mothers colonized with GBS, including 69 who received inadequate IAP. Of 69 neonates, nine showed symptoms, including respiratory distress, fever, tachycardia, vomiting, and irritability. Abnormalities in complete blood count (CBC) and C-reactive protein (CRP) were noted in three and four neonates, respectively. Three infants were diagnosed with EOGBS infection confirmed by positive rectal and throat cultures, and all three presented with respiratory distress and CRP abnormalities. Respiratory distress (p=0.0004) and CRP (p=0.0001) offered reliable indicators for detecting EOGBS infections.

Author List

Kojima K, Tanaka R, Nakajima K, Kurihara N, Oba MS, Yamashita Y, Ishihara J, Yahagi N

Author

Ryuma Tanaka MD Assistant Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Anti-Infective Agents
Antibiotic Prophylaxis
Blood Cell Count
C-Reactive Protein
Cohort Studies
Female
Humans
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical
Japan
Mothers
Prognosis
Retrospective Studies
Risk Factors
Streptococcal Infections
Streptococcus agalactiae