Faculty Collaboration Database

Blood flow capacity via direct acute myocardial revascularization. Basic Res Cardiol 1997 Feb;92(1):45-51

Date

02/01/1997

Pubmed ID

9062651

DOI

10.1007/BF00803756

Scopus ID

2-s2.0-0031053376 (requires institutional sign-in at Scopus site)   18 Citations

Abstract

The concept of direct myocardial revascularization, achieving myocardial perfusion through means other than the normal coronary vasculature, has a long history with the most widely investigated technique being the Vineberg procedure; current interest centers around the encouraging preliminary clinical results obtained with transmyocardial laser revascularization. Despite significant previous research, the acute blood flow potential through the direct myocardial route remains unknown. Nontransmural laser channels were made in the distal LAD territory from the epicardial surface of 5 mongrel dogs to which an internal mammary artery was connected. A flow probe was placed on the distal most portion of the artery and an intercostal branch was cannulated for infusion of colored microspheres. Measurements were taken under baseline conditions and following LAD and epicardial collateral ligation. Under all conditions, blood flow pattern was of a to-and-fro nature. At baseline, there was an average 0.60 +/- 0.24 ml/min net flow into the myocardium which was all contained within 0.5 cm of the central channel with a final myocardial perfusion of 0.011 +/- 0.016 ml/min/g. Following induction of ischemia average flow increased to 1.41 +/- 0.51 ml/min which extended as far as 1 cm from the channel with a final myocardial perfusion of 0.22 +/- 0.19 ml/min/g. In conclusion, a limited amount of acute myocardial perfusion can be achieved by the present technique of direct myocardial revascularization and the amount of flow is highly dependent upon the amount of flow through the native circulation.

Author List

Kohmoto T, Uzun G, Gu A, Zhu SM, Smith CR, Burkhoff D

Author

Takushi Kohmoto MD, PhD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Blood Flow Velocity
Cardiac Surgical Procedures
Coronary Artery Bypass
Coronary Circulation
Coronary Disease
Coronary Vessels
Dogs
Electrocardiography
Laser Therapy
Microspheres
Myocardial Revascularization