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Lessons learned from a lncRNA odyssey for two genes with vascular functions, DLL4 and TIE1. Vascul Pharmacol 2019 03;114:103-109

Date

03/27/2019

Pubmed ID

30910126

Pubmed Central ID

PMC6436643

DOI

10.1016/j.vph.2018.06.010

Abstract

Pervasive transcription is a feature of the human genome that requires better understanding. Over the last decade or so, RNA species longer than 200 nucleotides-dubbed long non-coding RNA (lncRNAs)-had been found in sense or anti-sense orientation within or outside of genes that encode proteins. Importantly, lncRNA-mediated gene regulation and the elements that control lncRNA expression are a source of fascination among molecular biologists. In vascular biology, a dozen or so lncRNAs had been identified, and progress occurs each day. In this review, we highlighted our laboratories' contribution to the lncRNA field by discussing lessons learned from two lncRNAs in the tyrosine kinase containing immunoglobulin and epidermal growth factor homology1 (Tie1) and delta-like 4 (Dll4) loci. These genes are responsible for basic vascular patterning and pathophysiological remodeling in angiogenesis.

Author List

Chowdhury TA, Li K, Ramchandran R

Author

Ramani Ramchandran PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Body Patterning
Gene Expression Regulation
Gene Expression Regulation, Developmental
Humans
Intercellular Signaling Peptides and Proteins
Intracellular Signaling Peptides and Proteins
Models, Animal
Neovascularization, Physiologic
RNA, Long Noncoding
Receptor, TIE-1
Signal Transduction
Vascular Remodeling
Zebrafish
Zebrafish Proteins
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d