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Diffusion Tensor Imaging in Acute Spinal Cord Injury: A Review of Animal and Human Studies. J Neurotrauma 2019 Aug 01;36(15):2279-2286

Date

04/06/2019

Pubmed ID

30950317

DOI

10.1089/neu.2019.6379

Scopus ID

2-s2.0-85071059121   14 Citations

Abstract

Diffusion tensor imaging (DTI), based on the property of preferential diffusion of water molecules in biological tissue, is seeing increasing clinical application in the pathologies of the central nervous system. Spinal cord injury (SCI) is one such area where the use of DTI allows for the evaluation of changes to microstructure of the spinal cord not detected on routine conventional magnetic resonance imaging. The insights obtained from pre-clinical models of SCI indicate correlation of quantitative DTI indices with histology and function, which points to the potential of DTI as a non-invasive, viable biomarker for integrity of white matter tracts in the spinal cord. In this review, we describe DTI alterations in the acute phase of SCI in both animal models and human subjects and explore the underlying pathophysiology behind these changes.

Author List

Kaushal M, Shabani S, Budde M, Kurpad S

Authors

Matthew Budde PhD Associate Professor in the Neurosurgery department at Medical College of Wisconsin
Shekar N. Kurpad MD, PhD Chair, Director, Professor in the Neurosurgery department at Medical College of Wisconsin
Saman Shabani MD Assistant Professor in the Neurosurgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Diffusion Tensor Imaging
Disease Models, Animal
Humans
Spinal Cord Injuries
White Matter