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Could the menagerie of the gut microbiome really cure cancer? Hope or hype. J Immunother Cancer 2019 04 02;7(1):92

Date

04/04/2019

Pubmed ID

30940203

Pubmed Central ID

PMC6444641

DOI

10.1186/s40425-019-0561-9

Scopus ID

2-s2.0-85063797873   10 Citations

Abstract

The investigational scale of the gut microbiome is expanding rapidly. In 2018, the intersection of gut microbiota and immuno-oncology received much attention. While the impact of gut microbiota on the immune system was already established, the year received an exponential expansion of microbiome's role in the immunotherapy setting. The microbiome research pipeline is ripe for large-scale, prospective trials. Working knowledge of immune-based cancer treatments, heterogeneity in their responses and resistance mechanisms, relevant immunological and microbiological pathways and potential for gut microbiome in enhancing the responses, is critical.

Author List

Abid MB

Author

Muhammad Bilal Abid MD Assistant Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Disease Management
Disease Susceptibility
Gastrointestinal Microbiome
Humans
Immunity
Immunotherapy
Neoplasms
T-Lymphocyte Subsets