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Renal nerves modulate kidney renin gene expression during the transition from fetal to newborn life. Am J Physiol 1992 Mar;262(3 Pt 2):R459-63

Date

03/01/1992

Pubmed ID

1373041

DOI

10.1152/ajpregu.1992.262.3.R459

Scopus ID

2-s2.0-0026607252   34 Citations

Abstract

The role of renal nerves in regulating changes in plasma renin activity (PRA) and renal renin gene expression was studied in intact (n = 6) and denervated (n = 6) fetal sheep before birth and during the first 24 h after delivery. Renal denervation completely blunted the rise in PRA observed 24 h after delivery in newborn lambs; in lambs with intact kidneys, PRA increased significantly (P less than 0.05) from 3.26 +/- 0.60 (predelivery) to 6.34 +/- 1.85 ng angiotensin I (ANG I).ml-1.h-1 (24 h postdelivery), while in lambs with denervated kidneys, predelivery and post-delivery values were 2.84 +/- 0.19 and 2.49 +/- 0.45 ng ANG I.ml-1.h-1, respectively. Renin mRNA levels were significantly lower (P less than 0.001) in denervated than in intact kidneys 24 h after birth. A close analysis of these results also revealed that renin mRNA levels were significantly higher (P less than 0.001) in intact kidneys of newborn lambs delivered vaginally (n = 3) than in newborn lambs delivered by cesarean section (n = 3). These results suggest that renal nerves play an important role in regulating renin gene expression and PRA during the transition from fetal to newborn life.

Author List

Page WV, Perlman S, Smith FG, Segar JL, Robillard JE

Author

Jeffrey L. Segar MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aging
Animals
Animals, Newborn
Autoradiography
Blotting, Northern
Denervation
Female
Gene Expression
Gene Expression Regulation, Enzymologic
Kidney
Phosphorus Radioisotopes
Pregnancy
RNA
Renin
Sheep
Sympathetic Nervous System
jenkins-FCD Prod-478 d1509cf07a111124a2d122fd3df854cc0b993c00