Possible noradrenergic involvement in naloxone potentiation of apomorphine-induced stereotypic climbing in mice. Pharmacol Biochem Behav 1984 Nov;21(5):733-6
Date
11/01/1984Pubmed ID
6096896DOI
10.1016/s0091-3057(84)80011-8Scopus ID
2-s2.0-0021689775 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Apomorphine-induced stereotypic climbing behavior in mice was significantly potentiated by pretreatment with the opiate receptor blocker naloxone. In animals additionally pretreated with alpha-methyl-p-tyrosine, brain levels of norepinephrine (NE) and dopamine (DA) were markedly reduced and naloxone potentiation of apomorphine-induced stereotypic climbing was blocked. In mice pretreated with diethyldithiocarbamic acid, brain NE was slightly reduced, brain DA was slightly elevated but naloxone potentiation of apomorphine-induced stereotypic climbing was unaltered. In animals pretreated with reserpine, both brain NE and DA were significantly reduced by naloxone potentiation of apomorphine-induced stereotypic climbing was not affected. In other experiments, pretreatment with low doses of the alpha-adrenergic receptor blocker BE-2254 failed to suppress climbing activity induced by apomorphine alone but did successfully prevent naloxone potentiation of apomorphine-induced stereotypic climbing. These findings suggest the possibility that NE and alpha-adrenergic receptors might play a role in the potentiating influence of naloxone upon apomorphine-induced stereotypic climbing activity in mice.
Author List
Quock RM, Bloom AS, Sadowski JAMESH terms used to index this publication - Major topics in bold
AnimalsApomorphine
Brain
Ditiocarb
Dopamine
Drug Synergism
Humans
Male
Methyltyrosines
Mice
Mice, Inbred ICR
Naloxone
Norepinephrine
Reserpine
Stereotyped Behavior
alpha-Methyltyrosine
