Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines. Org Lett 2019 May 03;21(9):3337-3341
Date
04/20/2019Pubmed ID
31002524DOI
10.1021/acs.orglett.9b01082Scopus ID
2-s2.0-85065092684 (requires institutional sign-in at Scopus site) 85 CitationsAbstract
The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products. The deaminative coupling reaction of 2-aminobenzamides with amines led to the efficient formation of quinazolinone products. The catalytic coupling method provides an efficient synthesis of quinazoline and quinazolinone derivatives without using any reactive reagents or forming any toxic byproducts.
Author List
Kirinde Arachchige PT, Yi CSAuthor
Chae Yi PhD Professor, Inorganic and Organometallic Chemistry, Homogeneous Catalysis in the Chemistry department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
AminesBenzamides
Catalysis
Coordination Complexes
Cycloaddition Reaction
Ketones
Ligands
Quinazolines
Quinazolinones
Ruthenium
