Alterations in resting-state functional connectivity in patients with Crohn's disease in remission. Sci Rep 2019 May 15;9(1):7412
Date
05/17/2019Pubmed ID
31092855Pubmed Central ID
PMC6520362DOI
10.1038/s41598-019-43878-0Scopus ID
2-s2.0-85065803806 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
Previous studies have found neural alterations in regions involved in cognitive and affective functions among Crohn's disease (CD) patients. The present work recruited 18 CD patients and 18 age-gender matched healthy controls (HC) and specifically compared differences in resting-state functional connectivity (RSFC) within the executive control network (ECN) which has been implicated in cognitive function and default mode network (DMN), which has been implicated in affective function. Additionally, we examined the correlations between RSFC in ECN and verbal fluency (VF) in both groups as well as RSFC in DMN and anxiety level in the CD group. Results showed significantly increased RSFC between the right middle frontal gyrus and right inferior parietal lobule in ECN, as well as increased RSFC between the right precuneus and right posterior cingulate cortex in DMN, among CD patients compared to HC. However, the correlations between ECN/DMN and behavioral scores in each group were not significant, which was possibility due to the limited sample size. These findings suggest that CD patients may experience changes in the connectivity patterns in ECN and DMN. Increased connectivity observed on these networks could be a potential biomarker of a neuropsychiatric manifestation of CD.
Author List
Hou J, Mohanty R, Nair VA, Dodd K, Beniwal-Patel P, Saha S, Prabhakaran VAuthor
Poonam Beniwal-Patel MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultBrain
Case-Control Studies
Cognition
Crohn Disease
Female
Gyrus Cinguli
Humans
Magnetic Resonance Imaging
Male
Neural Pathways
Neuroimaging
Parietal Lobe
Prefrontal Cortex
Remission Induction
