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Long Noncoding RNA: Genomics and Relevance to Physiology. Compr Physiol 2019 06 12;9(3):933-946

Date

06/13/2019

Pubmed ID

31187897

DOI

10.1002/cphy.c180032

Scopus ID

2-s2.0-85067798712   6 Citations

Abstract

The mammalian cell expresses thousands of long noncoding RNAs (lncRNAs) that are longer than 200 nucleotides but do not encode any protein. lncRNAs can change the expression of protein-coding genes through both cis and trans mechanisms, including imprinting and other types of transcriptional regulation, and posttranscriptional regulation including serving as molecular sponges. Deep sequencing, coupled with analysis of sequence characteristics, is the primary method used to identify lncRNAs. Physiological roles of specific lncRNAs can be examined using genetic targeting or knockdown with modified oligonucleotides. Identification of nucleic acids or proteins with which an lncRNA interacts is essential for understanding the molecular mechanism underlying its physiological role. lncRNAs have been reported to contribute to the regulation of physiological functions and disease development in several organ systems, including the cardiovascular, renal, muscular, endocrine, digestive, nervous, respiratory, and reproductive systems. The physiological role of the majority of lncRNAs, many of which are species and tissue specific, remains to be determined. © 2019 American Physiological Society. Compr Physiol 9:933-946, 2019.

Author List

Kong Y, Lu Z, Liu P, Liu Y, Wang F, Liang EY, Hou FF, Liang M

Authors

Mingyu Liang PhD Center Director, Professor in the Physiology department at Medical College of Wisconsin
Pengyuan Liu PhD Adjunct Professor in the Physiology department at Medical College of Wisconsin
Yong Liu PhD Assistant Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Cardiomegaly
Databases, Nucleic Acid
Diabetic Nephropathies
Endothelium, Vascular
Gene Expression Regulation
Genomics
Humans
Myocardial Infarction
Neovascularization, Pathologic
RNA, Long Noncoding
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d